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    <ns10:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/18579678"/>
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    <ns1:colonyMaintenance xml:lang="en">Homozygote x Homozygote [or Crossing to Slc:ICR]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="ja">Homozygote x Homozygote [or Crossing to Slc:ICR]</ns1:colonyMaintenance>
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    <dc:description xml:lang="en">Hes1 gene floxed mice.  LoxP sequences were knocked into the first intron and downstream of 3'UTR of Hes1 gene for conditional knock-out study.  PGK-Neo sequence was removed.</dc:description>
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    <ns1:strainDevelopment xml:lang="ja">京都大学ウィルス研究所・今吉　格、影山龍一郎（2007）。TT2 ES細胞由来を用いて作出。ICRと交配。</ns1:strainDevelopment>
    <ns1:ESCellLine>TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]</ns1:ESCellLine>
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    <ns4:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development. 2008 135(15):2531-41.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.  The RECIPIENT of BIOLOGICAL resource shall obtain a prior written consent on use of it from the DEPOSITOR Dr. Itaru Imayoshi (E-mail: iimayosh@virus.kyoto-u.ac.jp) and Ryoichiro Kageyama (E-mail: rkageyam@virus.kyoto-u.ac.jp ). (No approval form (Form D) is necessary).</ns4:termsAndConditions>
    <ns6:brs_depositor xml:lang="ja">影山龍一郎</ns6:brs_depositor>
    <rdfs:label>ICR.Cg-Hes1&lt;tm1Imayo&gt;</rdfs:label>
    <rdfs:label xml:lang="en">ICR.Cg-Hes1&lt;tm1Imayo&gt;</rdfs:label>
    <ns1:strainDevelopment xml:lang="en">Developed by Itaru Imayoshi and Ryoichiro Kageyama, Institute for Virus Research, Kyoto University in 2007.  TT2 ES cells were used.  The mutant mice were crossed to ICR.</ns1:strainDevelopment>
    <skos:altLabel xml:lang="ja">Hes1-floxed ; Hes1 floxed</skos:altLabel>
    <skos:altLabel xml:lang="en">Hes1-floxed ; Hes1 floxed</skos:altLabel>
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    <ns1:expectedDelivery xml:lang="en">D (more than 6 months)</ns1:expectedDelivery>
    <ns1:donorDNA>Bacteriophage P1 loxP sequence, Mouse Hes1 genomic DNA</ns1:donorDNA>
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    <ns6:brs_depositor xml:lang="en">Itaru IMAYOSHI</ns6:brs_depositor>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_congenic"/>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_24"/>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC05995"/>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:3808031"/>
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    >true</ns1:isRecombinant>
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    <dc:description xml:lang="ja">Hes1遺伝子のfloxedマウス。Hes1遺伝子の第一イントロン及び3'UTRの下流に、それぞれLoxPが挿入してある。Cre発現マウスと交配する事で、Hes1のコンディショナルノックアウトを行う事ができる。PGK-Neo配列は除去してある。</dc:description>
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    </ns6:brs_hasGenomicFeature>
    <ns6:brs_depositor xml:lang="en">Ryuichiro KAGEYAMA</ns6:brs_depositor>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_3"/>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Development. 2008 135(15):2531-41.&lt;br&gt;研究成果の公表にあたって謝辞の表明を必要とする。&lt;br&gt;学術機関の学術研究に限る。分与希望者は事前に今吉格(E-mail: iimayosh@virus.kyoto-u.ac.jp)と影山龍一郎 (Emai: rkageyam@virus.kyoto-u.ac.jp)の両方に連絡をとり、分与に関して許可を得ること。（提供承諾書（書式6）の提出は不要）。</ns4:termsAndConditions>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
    <ns6:brs_depositor xml:lang="ja">今吉　格</ns6:brs_depositor>
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